Generation of an induced pluripotent stem cell line, ZIPi021-A, from fibroblasts of a Prader-Willi syndrome patient with maternal uniparental disomy (mUPD)
oleh: Hannah Heseding, Kirsten Jahn, Björn Brändl, Alexandra Haase, Ian O. Shum, Tim Kohrn, Stefan Bleich, Helge Frieling, Ulrich Martin, Franz-Josef Müller, Stephanie Wunderlich, Maximilian Deest
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2023-09-01 |
Deskripsi
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by loss of paternal expression of imprinted genes on chromosome 15q11-q13. We established a human induced pluripotent stem cell line (hiPSC), ZIPi021-A, from fibroblasts of a 4-year-old female PWS patient with the subtype of maternal uniparental disomy (mUPD). The generated hiPSC line was transgene-free, expressed pluripotency markers and showed the ability to differentiate into all three germ layers in vitro. The ZIPi021-A hiPSC line could be used as a cellular model for PWS in humans.