Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks
oleh: Pauline Chanut, Sébastien Britton, Julia Coates, Stephen P. Jackson, Patrick Calsou
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-09-01 |
Deskripsi
Homologous recombination requires end resection of the DNA at the site of the break, however the Ku dimer can sequester single-ended double-strand breaks. Here the authors show that ATM-dependent phosphorylation of CtIP, along with the actions of Mre11, impair the stable loading of Ku onto DNA.