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This paper mainly studies the therapeutic effect of azithromycin and hydroxychloroquine on COVID-19. Severe acute respiratory syndrome is one of the key clinical manifestations of COVID-19, and azithromycin is considered to be a feasible treatment. The purpose of this study is to investigate how to use azithromycin to treat COVID-19 better. This article describes the therapeutic effect of azithromycin alone on COVID-19, and the effect of azithromycin and hydroxychloroquine when used in combination with COVID-19. Several studies have shown that although azithromycin has antiviral activity, azithromycin alone has no significant effect on the treatment of COVID-19. In contrast, multiple data show that the combination of azithromycin and hydroxychloroquine has some efficacy in the treatment of COVID-19, and the efficacy is related to the number of days the patient has been ill. The discovery impacts the treatment by providing a different perspective on the world’s treatment of COVID-19.