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In the molecule of the title compound, C16H12N2O4, the pyridine ring is oriented at the same dihedral angle of 2.92 (3)° with respect to the furan and isoxazole rings, while the dihedral angle between furan and isoxazole rings is 1.34 (3)°. The dihedral angle between the benzene and pyridine rings is 53.23 (3)°. In the crystal structure, intermolecular C—H...O interactions link the molecules into chains. Weak π–π contacts between isoxazole and benzene rings [centroid–centroid distance = 3.969 (3) Å] may further stabilize the structure.