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Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis
oleh: Quanbin Zha, Xi Wu, Jingxin Zhang, Tingting Xu, YongKang Shi, Yayun Sun, Yuan Fang, Yunru Gu, Pei Ma, Yongqian Shu, Shengwang Tian
Format: | Article |
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Diterbitkan: | Nature Publishing Group 2022-03-01 |
Deskripsi
Abstract Circular RNAs are an important kind of noncoding RNAs and involved in cancerogenesis, but the specific mechanism between gastric cancer and circRNAs needs further study. Hsa_circ_0007967 was selected by RNA sequencing. Here, hsa_circ_0007967 was highly expressed in gastric cancer tissues than adjacent normal tissues. Overexpressing hsa_circ_0007967 promoted gastric cancer cell proliferation in vitro and in vivo, while suppression of hsa_circ_0007967 inhibited gastric cancer cell proliferation in vitro and in vivo. Mechanistically, hsa_circ_0007967 sponged miR-411-5p to increase MAML3 expression. Overall, hsa_circ_0007967 is a promising biomarker for gastric cancer diagnosis and a potential molecule for gastric cancer treatment.