Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation
oleh: Eva Maria Wenzel, Sebastian Wolfgang Schultz, Kay Oliver Schink, Nina Marie Pedersen, Viola Nähse, Andreas Carlson, Andreas Brech, Harald Stenmark, Camilla Raiborg
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-07-01 |
Deskripsi
Intraluminal vesicles are formed by the endosomal sorting complex required for transport (ESCRT) machinery. Here, the authors unravel the timing of vesicle budding, and that endosomal clathrin regulates concerted recruitment of ESCRT subcomplexes, required for efficient membrane remodeling.