Extension of the 5-alkynyluridine side chain via C–C-bond formation in modified organometallic nucleosides using the Nicholas reaction
oleh: Renata Kaczmarek, Dariusz Korczyński, James R. Green, Roman Dembinski
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2020-01-01 |
Deskripsi
Dicobalt hexacarbonyl nucleoside complexes of propargyl ether or esters of 5-substituted uridines react with diverse C-nucleophiles. Synthetic outcomes confirmed that the Nicholas reaction can be carried out in a nucleoside presence, leading to a divergent synthesis of novel metallo-nucleosides enriched with alkene, arene, arylketo, and heterocyclic functions, in the deoxy and ribo series.