Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine
oleh: Kai-Bo Wang, Yushuang Liu, Jinzhu Li, Chengmei Xiao, Yingying Wang, Wei Gu, Yipu Li, Yuan-Zheng Xia, Tingdong Yan, Ming-Hua Yang, Ling-Yi Kong
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-10-01 |
Deskripsi
The G-quadruplex formed in KRAS oncogene promoter (KRAS-G4) is a transcriptional modulator and amenable to small molecule targeting. Herein, the authors report the NMR solution structures of a bulge-containing KRAS-G4 that bound to two small molecules. The study provides molecular details of ligand interactions with KRAS-G4 and contributes insight into the design of specific KRAS-G4-interactive drugs.