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The prime objective of the current study was to comparative the impact of Transcranial Direct Current Stmulation (tDCS) on the Cognitive flexibility of hyperactive student-athletes. In this study, amongst the79 children diagnosed with ADHD, 30 students were randomly selected and divided into two groups of 15 people, control and experimental, based on age, sex and pre-test results performed by the wisconsin card sorting test (WCST) . All subjects in the two groups received two different types of single-position and dummy anode stimulation on the area (F3) with cathode excitation in the area (SO) with a current of 1 mA for 15 minutes for ten sessions (p≤0.05) and after ten sessions, each group was re-examined. After one month, a follow-up test was performed according to the post-test with using the wisconsin card sorting test (WCST) and multivariate analysis of covariance was used to test statistical hypotheses. (p≤0.05). The results obtained by multivariate analysis of covariance revealed that applying single-session anodal tDCS influenced Cognitive flexibility of hyperactive student-athletes, and it led to a significant difference between the experimental and sham groups. The findings of the study indicated that the protocol of applying single-session anodal tDCS has the ability to improve the cognitive flexibility of hyperactive student-athletes.