Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins
oleh: Andrea Mascitti, Massimiliano Lupacchini, Ruben Guerra, Ilya Taydakov, Lucia Tonucci, Nicola d’Alessandro, Frederic Lamaty, Jean Martinez, Evelina Colacino
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2017-01-01 |
Deskripsi
The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG). A comparative study under dry-grinding conditions was also performed. The results showed that the cyclization reaction was influenced by the amount of the PEG grinding agents. In general, cleaner reaction profiles were observed in the presence of PEGs, compared to dry-grinding procedures.