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Guillain Barre Syndrome is an acute poly neuropathy, a disorder affecting the peripheral nervous system. The typical symptoms are ascending paralysis, weakness starting at the feet and hands, migrating towards the trunk. Ours is a prospective study related to the effect of plasma pheresis in the treatment of Guillain Barre syndrome along with neurology & General Medicine departments. So far 10 patients were subjected to plasmapheresis along with the conventional treatment and physiotherapy. All the patients recovered completely.