Synthesis of Poly-Substituted Quinolines via Friedländer Hetero-Annulation Reaction Using Silica-Supported P2O5 under Solvent-Free Conditions
oleh: Alireza Hasaninejad, Abdolkarim Zare, Mohammad Ali Zolfigol, Marzieh Abdeshah, Arash Ghaderi, Fatemeh Nami-Ana
| Format: | Article |
|---|---|
| Diterbitkan: | Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR 2011-03-01 |
Deskripsi
A highly efficient, simple and green solvent-free protocol for the preparation of poly-substituted quinolines via Friedländer hetero-annulation reaction between 2-aminoaryl ketones and carbonyl compounds in the presence of silica-supported P2O5 (P2O5 / SiO2) is described. In this method, the title compounds are obtained in high to excellent yields and in short reaction times.