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Introduction: To compare post-operative infectious morbidity in patients undergoing elective cesarean section with administration of antibiotic before skin incision and after cord clamping Methods: In this prospective, double-blind, randomized controlled trial all the women of age 18-40 years, being scheduled for cesarean section on elective list due to any reason, were included. They were divided into two groups: Group A included pre-incision group and Group B included cord-clamp group. Patients in group A were given 1G Ceftriaxone intravenously (IV), about 15-30 minutes before skin incision while in group B patients; antibiotic was administered after cord clamping. Post-operatively, patients were assessed for wound infection, endometritis, pyelonephritis, UTI and overall infectious morbidity. Results: A total of 174 patients were enrolled in the study. The mean age of the patients was 27.17 ± 4.68 years. The demographic characteristics were generally evenly distributed in both groups. Maternal outcomes in both groups including wound infection,urinary tract infections, endometriosis, pyelonephritis and overall infectious morbidity did not reach a statistically significant level. Conclusion: Administration of prophylactic antibiotic at 30–60 min before skin incision resulted in better maternal outcome than after cord clamp. However it is not significant and we recommend more clinical trials.