Identification of drug-specific public TCR driving severe cutaneous adverse reactions
oleh: Ren-You Pan, Mu-Tzu Chu, Chuang-Wei Wang, Yun-Shien Lee, Francois Lemonnier, Aaron W. Michels, Ryan Schutte, David A. Ostrov, Chun-Bing Chen, Elizabeth Jane Phillips, Simon Alexander Mallal, Maja Mockenhaupt, Teresa Bellón, Wichittra Tassaneeyakul, Katie D. White, Jean-Claude Roujeau, Wen-Hung Chung, Shuen-Iu Hung
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-08-01 |
Deskripsi
Severe cutaneous adverse reactions (SCAR) is a T cell-mediated, potentially lethal drug hypersensitivity (DH). Here, the authors identify a carbamazepine-specific TCR common among patients with carbamazepine-induced SCAR that confers SCAR-like pathology in mice upon carbamazepine exposure, thereby implicating specific TCRs in DH etiology.