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Background: Lateral epicondylitis is one of the common conditions in the elbow joint. Muscles and soft tissue around the elbow are predominantly involved in lateral epicondylitis, studies identified that extensor muscles specifically extensor carpi radialis brevis (ECRB) is affected due to vigorous and repeated wrist movements. Multiple management strategies have been identified ranging from conservative to surgical, Cryotherapy to ergonomic advices, but still the results are inconclusive. Objectives: The objective is to find out the effect of Myofascial Release Therapy (MFR) and Active Stretching on pain and grip strength in Lateral Epicondylitis. Methodology: Quasi experimental study design with 42 sample size was selected for the study in consideration of the inclusion and exclusion criteria. Study was approved by the institutional ethical committee. The participants were divided into two groups, group I underwent myofascial release therapy with active stretching, and group II underwent only active stretching for 8 weeks, All participants receive treatment thrice weekly. The outcome measures selected were pain and grip strength. Pain was assessed through visual analog scale and the grip strength was assessed through Hand held Smedley spring dynamometer Results: The results were analysed using Mann Whitney U test to compare the difference between the experimental group and control group. The result shows that adding Myofasical release therapy with active stretching produce a significant improvement in pain reduction and the grip strength in the patients with lateral epicondylitis. Conclusion: The study concluded that adding MFR with active stretching produces significant reduction of pain and improvement of the function in lateral epidcondylitis. Key words: Lateral epicondylitis, Myofascial release therapy, Active stretching, Grip strength. Pain.