Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry
oleh: David Kachaner, Damien Garrido, Haytham Mehsen, Karine Normandin, Hugo Lavoie, Vincent Archambault
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-11-01 |
Deskripsi
Drosophila Polo kinase is the founding member of the Polo-Like Kinase (PLK) family and a master regulator of mitosis and cytokinesis. Here the authors uncover a molecular mechanism for the spatiotemporal regulation of Polo kinase during mitotic entry through a phosphorylation event that triggers nuclear import.