Self assembling nanoparticle enzyme clusters provide access to substrate channeling in multienzymatic cascades
oleh: Joyce C. Breger, James N. Vranish, Eunkeu Oh, Michael H. Stewart, Kimihiro Susumu, Guillermo Lasarte-Aragonés, Gregory A. Ellis, Scott A. Walper, Sebastián A. Díaz, Shelby L. Hooe, William P. Klein, Meghna Thakur, Mario G. Ancona, Igor L. Medintz
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-03-01 |
Deskripsi
Channeling between enzymes is a uniquely nanoscale phenomenon that can improve multienzymatic reaction rates. Here, the authors demonstrate that multistep enzyme cascades can self-assemble with nanoparticles into nanoclusters that access channeling and improve the underlying catalytic flux by several fold.