Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development
oleh: Priya D. Issuree, Kenneth Day, Christy Au, Ramya Raviram, Paul Zappile, Jane A. Skok, Hai-Hui Xue, Richard M. Myers, Dan R. Littman
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-09-01 |
Deskripsi
The expression of CD4, a critical co-receptor providing T cell help in adaptive immunity, is finely tuned during development. Here the authors show that two enhancer elements, E4p and the newly-defined E4m, coordinate the expression and heritable demethylation of Cd4 in thymocytes but are dispensable for its sustained expression in peripheral T cells.