Daring the Challenge and Thinking Big: The Value of Early Process R&D
oleh: Stefan Abele, Jacques-Alexis Funel, Gunther Schmidt, Christian Moessner, Mischa Schwaninger, Roger Marti
| Format: | Article |
|---|---|
| Diterbitkan: | Swiss Chemical Society 2016-08-01 |
Deskripsi
The production of the L/T channel blocker ACT-280778 required the enantiomerically pure 5-phenylbicyclo[2.2.2]oct-5-en-2-one (1) as key building block. As the published routes towards 1 are very low yielding (