Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints
oleh: Yvonne H. Chan, Sergey V. Venev, Konstantin B. Zeldovich, C. Robert Matthews
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-03-01 |
Deskripsi
The TIM barrel fold is an evolutionarily conserved motif found in proteins with a variety of enzymatic functions. Here the authors explore the fitness landscape of the TIM barrel protein IGPS and uncover evolutionary constraints on both sequence and structure, accompanied by long range allosteric interactions.