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The brain has limited innate ability to promote repair, regeneration and functional recovery following injury, disease, or developmental disorder. Although cell and gene therapies have significant potential in the brain, no single treatment is likely to succeed in isolation. Here we discuss the current state of the art in cell and nucleic-acid-based neurotherapeutics and argue for the development of combination therapies that use biomaterials to help overcome the current limitations of cell and gene therapies alone.