Increased Expression of the Calcium-Activated Chloride Channel in Hclca1 in Airways of Patients with Obstructive Chronic Bronchitis
oleh: Hans-Peter Hauber, Celine Bergeron, Anne Tsicopoulos, Benoit Wallaert, Ron Olivenstein, Kenneth J Holroyd, Roy C Levitt, Qutayba Hamid
| Format: | Article |
|---|---|
| Diterbitkan: | Hindawi Limited 2005-01-01 |
Deskripsi
BACKGROUND: Interleukin (IL)-9 and its effect on enhancing the human calcium-activated chloride channel 1 (hCLCA1) expression have been shown to induce mucin production. Increased expression of hCLCA1 may, in turn, contribute to mucus overproduction in chronic obstructive pulmonary disease (COPD) with a chronic bronchitis (CB) phenotype.