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Background: Several studies have shown the dangers of cigarette smoking among daily smokers. However, another group that has recently been investigated is a nondaily smoking group. The nondaily smokers experience the adverse health effects of smoking more than nonsmokers. This study aimed to evaluate the prevalence of depression and anxiety among daily and nondaily smokers. Materials and Methods: In this cross-sectional study with snowball sampling, 385 male residents of Kashan were selected and divided into three groups of daily smokers (118), nondaily smokers (114) and nonsmokers (135). Depression and anxiety were measured by the Beck depression inventory and beck anxiety inventory. Results: The results of the current study showed no significant difference in the prevalence of depression and anxiety in both daily and nondaily smokers (P<0.05). Also, depression and anxiety levels in daily smokers and nondaily smokers were significantly higher than nonsmokers (P<0.05). Conclusion: The prevalence of depression and anxiety among nondaily smokers is the same as the daily smokers. Thus, in both groups, in addition to smoking, special attention should be paid to anxiety and depression disorders.