Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model
oleh: Albert Giralt, Veronica Brito, Quentin Chevy, Clémence Simonnet, Yo Otsu, Carmen Cifuentes-Díaz, Benoit de Pins, Renata Coura, Jordi Alberch, Sílvia Ginés, Jean-Christophe Poncer, Jean-Antoine Girault
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-05-01 |
Deskripsi
Several kinases regulate spine morphology and plasticity. Here, the authors show that the tyrosine kinase Pyk2 regulates hippocampal plasticity and contributes to cognitive and hippocampal plasticity deficits in a mouse model of Huntington’s disease.