Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB
oleh: Simon N. Willis, Julie Tellier, Yang Liao, Stephanie Trezise, Amanda Light, Kristy O’Donnell, Lee Ann Garrett-Sinha, Wei Shi, David M. Tarlinton, Stephen L. Nutt
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-11-01 |
Deskripsi
Although important for early development, PU.1 is dispensable for mature B cell function, possibly owing to compensation by the related transcription factor SpiB. Here the authors show PU.1 and SpiB are collectively required for humoral immunity, through regulation of germinal centre formation and plasma cell differentiation.