Retinol saturase coordinates liver metabolism by regulating ChREBP activity
oleh: Steffi Heidenreich, Nicole Witte, Pamela Weber, Isabel Goehring, Alexander Tolkachov, Christian von Loeffelholz, Stephanie Döcke, Michael Bauer, Martin Stockmann, Andreas F. H. Pfeiffer, Andreas L. Birkenfeld, Matthias Pietzke, Stefan Kempa, Matthias Muenzner, Michael Schupp
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-08-01 |
Deskripsi
Fatty liver is one of the major features of metabolic syndrome and its development is associated with deregulation of systemic lipid and glucose homeostasis. Here Heidenreich et al. show that retinol saturase is implicated in hepatic lipid metabolism by regulating the activity of the transcription factor ChREBP.