Synthesis and evaluation of variably substituted N-methyl tetrahydroisoquinolines and benzazepines as monoamine reuptake inhibitors
oleh: Sneh Lata, Ashish Dhir, S.V. Kessar, K.N. Singh, S.K. Kulkarni, Pushpinder Singh
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2022-01-01 |
Deskripsi
The use of N-methyl-1, 2, 3, 4-tetrahydroisoquinoline as pharmacophores has been studied over the years. It has a structural similarity with the N, N-dimethyl phenethylamine, a framework entrenched in the drug venlafaxine, acknowledged for its antidepressant activity. In this work, the synthesis of β-substituted N-methyl-1, 2, 3, 4-tetrahydroisoquinolines and benzazepines was achieved and their application as potent monoamine reuptake inhibitors for neurological disorders was studied.