Bioactive Compounds from Andean Berry (<i>Vaccinium meridionale</i> Swartz) Juice Inhibited Cell Viability and Proliferation from SW480 and SW620 Human Colon Adenocarcinoma Cells
oleh: Myriam L. Agudelo-Quintero, Ivan Luzardo-Ocampo, Jorge A. Lopera-Rodríguez, Maria E. Maldonado-Celis, Sandra S. Arango-Varela
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2022-09-01 |
Deskripsi
The Andean berry is a South American fruit displaying anti-cancer effects. This research aimed to assess the antiproliferative effects of the juice (ABJ) on two human colon cells (SW480/SW620) through viability, proliferation, and Ki67 protein quantification. All treatments (0–30% <i>v</i>/<i>v</i>) reduced viability (<80%) and proliferation, being 30% most effective (IC<sub>50</sub>-SW480: 28.19% <i>v</i>/<i>v</i> ABJ; IC<sub>50</sub>-SW620: 19.43% <i>v</i>/<i>v</i> ABJ). All ABJ-treated cells showed a reduced ki67 amount compared to untreated cells. The highest binding affinity (−9.4 kcal/mol) was shown between cyanidin-3-glucoside and caspase 8 in silico. ABJ exerts antiproliferative/inhibitory effects on SW480/SW620 cells, attributable to polyphenol-apoptotic target interactions.