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Background & Aim: Promotion of patient satisfaction is one of the foremost goals for healthcare managers. Patient satisfaction is defined as the interactions between healthcare professionals and recipients of care, which is correlated with the connection of nurses with their profession. The present study aimed to evaluate the association between psychological wellbeing in nurses and patient satisfaction considering the intermediary role of job burnout. Materials and Methods: This descriptive-correlational study was conducted on all the nurses employed in the governmental hospitals in Lorestan province, Iran (n=2,602) in 2018. Samples size was determined at 335 based on the Cochrane’s formula, and the subjects were selected via convenience sampling. Data were collected using the questionnaire of psychological wellbeing by Sam Aram and Mahboobi (2014), patient satisfaction inventory (PSI), and Maslach burnout inventory (MBI). Data analysis was performed using descriptive statistics and structural equations. Results: Psychological wellbeing had a direct (β=0.40) and an indirect association (β=0.44) with the intermediary role of job burnout, which affected patient satisfaction (β=0.84). Moreover, psychological wellbeing influenced job burnout (β=0.72) and patient satisfaction (β=0.62). Conclusion: Considering the intermediary role of job burnout, psychological wellbeing had a positive impact on patient satisfaction. Therefore, it is recommended that healthcare managers enhance patient satisfaction through increasing psychological wellbeing and eliminating the influential factors in job burnout.