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Background: Patients with Langerhans cell histiocytosis are at particularly high risk for central diabetes insipi-dus (CDI) due to hypothalamic-pituitary disease. Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the proliferation of specialized bone marrow-derived Langerhans cells and mature eosinophils. Three disease variants were included in this description, eosinophilic granuloma, Letterer–Siwe disease and Hand–Schuller–Christian syndrome. Case Reprort: We report a patient of Langerhans cell histiocytosis-solitary eosinophilic granuloma of the mand-ible that presented with diabetes insipitus after biopsy of mass. Keywords: Langerhans cell histiocytosis (LCH), Eosinophilic granuloma, Mandible, Diabetes insipidus.