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Whenever there is a close relationship between radix of mandibular teeth and inferior alveolar nerve (IAN), the IAN may be at risk during endodontic therapy. Overinstrumentation, overfilling irrigation fluids, as well as spread of infection, are the known causes of IAN damage. The following article regards two cases of IAN damage following endodontic therapy. In one case, surgical decompression with the use of piezosurgical techniques (Piezomed®) was performed, after which the pain and dysesthesia gradually subsided over the weeks following surgery. The second case was managed with medication only; the complaints reduced within 3 months. It is important to treat IAN damage as early as possible to achieve the best outcome.