A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge
oleh: Biao Zhou, Runhong Zhou, Bingjie Tang, Jasper Fuk-Woo Chan, Mengxiao Luo, Qiaoli Peng, Shuofeng Yuan, Hang Liu, Bobo Wing-Yee Mok, Bohao Chen, Pui Wang, Vincent Kwok-Man Poon, Hin Chu, Chris Chung-Sing Chan, Jessica Oi-Ling Tsang, Chris Chun-Yiu Chan, Ka-Kit Au, Hiu-On Man, Lu Lu, Kelvin Kai-Wang To, Honglin Chen, Kwok-Yung Yuen, Shangyu Dang, Zhiwei Chen
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-06-01 |
Deskripsi
SARS-CoV-2 variants of concern such as the Omicron variant pose a challenge for vaccination and antibody immunotherapy. Here, Zhou et al. isolate a broadly neutralizing antibody (bNAb), named ZCB11, that protects Golden Syrian hamsters against Omicron. Applying CryoEM the authors show that ZCB11 heavy chain predominantly interacts with RBD in up confirmation, which interferes with ACE2 receptor binding.