A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells
oleh: Alex J. Pollock, Shivam A. Zaver, Joshua J. Woodward
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-07-01 |
Deskripsi
Cyclic dinucleotides are conserved second messengers but current detection methods are limited. Here the authors engineer a Förster resonance energy transfer (FRET) based biosensor, BioSTING, which gives real-time in vitro detection of these nucleotides.