ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking
oleh: Man-Xiu Xie, Xian-Ying Cao, Wei-An Zeng, Ren-Chun Lai, Lan Guo, Jun-Chao Wang, Yi-Bin Xiao, Xi Zhang, Di Chen, Xian-Guo Liu, Xiao-Long Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-03-01 |
Deskripsi
The molecular mechanisms mediating nociception are unclear. Here, the authors show that the Activating Transcription Factor 4 (ATF4) is important for the response to heat nociception in mice and ATF4 role in mediating protein trafficking in dorsal root ganglion neurons.