DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer
oleh: Andrew E Teschendorff, Yang Gao, Allison Jones, Matthias Ruebner, Matthias W. Beckmann, David L. Wachter, Peter A. Fasching, Martin Widschwendter
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-01-01 |
Deskripsi
Altered epigenetics is a feature of cancer but whether these changes occur early in tumour development is unclear. Here, the authors analyse methylation events in breast cancer and adjacent normal pairs, and show that methylation changes in the normal tissue are also found in the tumour, suggesting that some of these events occur early in cancer.