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Objective To investigate the efficacy of C2 dorsal root ganglion(DRG) pulsed radiofrequency(PRF) combined with ozonated autohemotherapy(OAHT) in the treatment of elderly patients with cervicogenic headache(CEH). Methods A total of eighty-five patients with CEH admitted to China-Japan Union Hospital of Jilin University from November 2020 to November 2021 were selected for review,and 48 effective cases were identified according to the inclusion and exclusion criteria and divided into PRF group and PRF+OAHT group according to the treatment plan.A total of 22 patients in the PRF group were treated with PRF for C2 DRG,and 26 patients in the PRF+OAHT group were treated with PRF for C2 DRG combined with OAHT once daily for 1 week.Visual analogue scale(VAS) was recorded before treatment,1 day,1 week and 1 month after treatment,and cervical range of motion(ROM) score was recorded before treatment and 1 month after treatment;the overall clinical response rate was used to assess the clinical effect,and the complications and adverse reactions during treatment were recorded. Results After treatment,VAS score was lower than that before treatment(P<0.05),ROM score was lower than that before treatment(P<0.05);1 week and 1 month after treatment,VAS score in PRF+OAHT group was lower than that in PRF group(P<0.05);the effective rate was more than 90% in both groups,and the difference was not statistically significant(P>0.05). Conclusion The effect of PRF+OAHT group was better than PRF group in relieving senile CEH.Both methods could relieve cervical limitation caused by CEH,and the effect was basically the same,close to the normal level after treatment.