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We report the first case of domino living donor liver transplantation in Korea; the first recipient was a 58-year-old woman with amyloidosis, and the second recipient was a 64-year-old man with downstaged hepatitis B virus related hepatocellular carcinoma. He had segmental portal vein tumor thrombosis initially, which disappeared by several locoregional therapies and radiation. We successfully performed domino living donor liver transplantation. A liver graft from a patient with amyloidosis is an effective and valuable source for patients without potential living liver donors.