Impact of IL-32 on Histamine Release by Human Derived Umbilical Cord Blood Mast Cells
oleh: M.L. Castellani, E. Toniato, P. Felaco, C. Ciampoli, D. De Amicis, C. Orso, C. Cucurullo, J. Vecchiet, S. Tetè, V. Salini, A. Caraffa, F. Pandolfi, P.L. Antinolfi, G. Cerulli, F. Conti, M. Fulcheri, G. Sabatino, P. Boscolo, Y.B. Shaik
| Format: | Article |
|---|---|
| Diterbitkan: | SAGE Publishing 2009-09-01 |
Deskripsi
IL-32 is onae of the last important cytokines discovered, produced mainly by T cells, natural killer cells, and epithelial cells. Probably many other different cells are a source of IL-32, which has been found to be a powerful pro-inflammatory mediator. Here we studied the effect of IL-32 on histamine release by human-derived cord-blood mast cells. In these studies we found that IL-32 significantly stimulates the release of histamine only at high concentrations (100 ng/ml) while at 10 or 50 ng/ml it had no effect. These results were found for the first time and demonstrate that IL-32 may play an important role in allergic and inflammatory diseases.