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<p>Abstract</p> <p>Background</p> <p>MED28 (also known as EG-1 and magicin) has been implicated in transcriptional control, signal regulation, and cell proliferation. MED28 has also been associated with tumor progression in <it>in </it><it>vitro </it>and <it>in vivo </it>models. Here we examined the association of MED28 expression with human breast cancer progression.</p> <p>Methods</p> <p>Expression of MED28 protein was determined on a population basis using a high-density tissue microarray consisting of 210 breast cancer patients. The association and validation of MED28 expression with histopathological subtypes, clinicopathological variables, and disease outcome was assessed.</p> <p>Results</p> <p>MED28 protein expression levels were increased in ductal carcinoma <it>in situ </it>and invasive ductal carcinoma of the breast compared to non-malignant glandular and ductal epithelium. Moreover, MED28 was a predictor of disease outcome in both univariate and multivariate analyses with higher expression predicting a greater risk of disease-related death.</p> <p>Conclusions</p> <p>We have demonstrated that MED28 expression is increased in breast cancer. In addition, although the patient size was limited (88 individuals with survival information) MED28 is a novel and strong independent prognostic indicator of survival for breast cancer.</p>