Find in Library

Four new xanthene derivatives, penicixanthenes A&#8722;D (<b>1</b>&#8722;<b>4</b>), and one known compound <b>5</b> were isolated from a marine mangrove endophytic fungus <i>Penicillium</i> sp. JY246 that was obtained from the stem of <i>Ceriops tagal</i>. Their structures were determined by detailed NMR, MS spectroscopic data, modified Mosher&#8217;s method, and calculated electronic circular dichroism data. All of the isolated compounds were examined for insecticidal activity. Compounds <b>2</b> and <b>3</b> showed growth inhibition activity against newly hatched larvae of <i>Helicoverpa armigera</i> Hubner with the IC₅₀ values 100 and 200 &#956;g/mL, respectively, and compounds <b>1</b>, <b>3</b>, and <b>4</b> showed insecticidal activity against newly hatched larvae of <i>Culex quinquefasciatus</i> with LC₅₀ values of 38.5 (&#177;1.16), 11.6 (&#177;0.58), and 20.5 (&#177;1) &#956;g/mL, respectively. The four xanthene derivatives have the potential to be developed as new biopesticides.