Neprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides
oleh: Ronja Schiemann, Annika Buhr, Eva Cordes, Stefan Walter, Jürgen J. Heinisch, Paola Ferrero, Hendrik Milting, Achim Paululat, Heiko Meyer
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-07-01 |
Deskripsi
Muscle contraction depends on strictly controlled calcium transients within myocytes. Here, the authors show that the endopeptidase Neprilysin 4 represents an essential regulator of these transients and, consequently, of proper heart function.