Synthesis of ribavirin 2’-Me-C-nucleoside analogues
oleh: Fanny Cosson, Aline Faroux, Jean-Pierre Baltaze, Jonathan Farjon, Régis Guillot, Jacques Uziel, Nadège Lubin-Germain
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2017-04-01 |
Deskripsi
An efficient synthetic pathway leading to two carbonated analogues of ribavirin is described. The key-steps in the synthesis of these ribosyltriazoles bearing a quaternary carbon atom in the 2’-position are an indium-mediated alkynylation and a 1,3-dipolar cyclization.