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<p>Abstract</p> <p>Background -</p> <p>Deep penetrating nevus (DPN) is a distinct variant of melanocytic nevus and remains a histopathologic challenge to pathologists because of its resemblance to blue nevus, malignant melanoma, pigmented Spitz nevus, and congenital melanocytic nevus. It often goes unrecognized due to its relative rarity.</p> <p>Case presentation -</p> <p>Here we report a case of DPN of the left anterior leg in a 51-year old female. A brief review of the literature shows that these lesions have a distinct growth pattern and cellular morphology that can differentiate these lesions from other entities including malignant melanoma.</p> <p>Conclusion -</p> <p>It is important to recognize these features because DPN carries a better prognosis than malignant melanoma.</p>