Haploinsufficiency of the lysosomal sialidase NEU1 results in a model of pleomorphic rhabdomyosarcoma in mice

oleh: Eda R. Machado, Diantha van de Vlekkert, Heather S. Sheppard, Scott Perry, Susanna M. Downing, Jonathan Laxton, Richard Ashmun, David B. Finkelstein, Geoffrey A. Neale, Huimin Hu, Frank C. Harwood, Selene C. Koo, Gerard C. Grosveld, Alessandra d’Azzo

Format: Article
Diterbitkan: Nature Portfolio 2022-09-01

Deskripsi

A mouse model of pleomorphic rhabdomyosarcoma, an aggressive and treatment-resistant form of pediatric sarcoma, provides an ideal tool for future diagnostic and therapeutic studies.