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This study investigated different approaches to optimize flows in misaligned culverts. Structures aligned with the natural stream are always preferred, as misalignments cause a change of direction at the culvert inlet associated with lower performance and sedimentation and erosion problems. This optimal positioning can cause high financial costs and a flow optimization minimizing the associated problems could be a viable alternative. In this study, we used computational fluid dynamics analysis to evaluate the flow in 44 different scenarios with misalignment angles ranging from 0<inline-formula> <math display="inline"> <semantics> <mo>&#176;</mo> </semantics> </math> </inline-formula> to 90<inline-formula> <math display="inline"> <semantics> <mo>&#176;</mo> </semantics> </math> </inline-formula>. It was found that smooth transitions towards the narrowest point in the stream (culvert) were possible for any degree of misalignment resulting in improved, uniform velocity distributions and less turbulence. An experimental setup was able to confirm the possible flow improvements. The proposed approach of flow redirection can lower construction costs and gives planners and designers more flexibility as tailored reinforcement and redesign of the stream embankment can be used as an alternative to costly creek alignments.