Inflammation promotes resistance to immune checkpoint inhibitors in high microsatellite instability colorectal cancer
oleh: Qiaoqi Sui, Xi Zhang, Chao Chen, Jinghua Tang, Jiehai Yu, Weihao Li, Kai Han, Wu Jiang, Leen Liao, Lingheng Kong, Yuan Li, Zhenlin Hou, Chi Zhou, Chenzhi Zhang, Linjie Zhang, Binyi Xiao, Weijian Mei, Yanbo Xu, Jiayi Qin, Jian Zheng, Zhizhong Pan, Pei-Rong Ding
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
Inflammatory conditions often affect colorectal cancer patients, and their effect on their ongoing treatment is a pressing medical question. Here authors show that inflammation interferes with local anti-tumour immune response and inhibits response to immune checkpoint blockade therapy via immunosuppressive neutrophil leukocytes.