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This new 8-page article presents an overview on the use of trunk injection for the targeted delivery of protection materials to agricultural crops to manage pests and diseases. Different methods of injection are described along with the underlying plant physiological principles, possible implications on the tree, and other concerns and considerations. Written by Leigh Archer, Ute Albrecht, and Jonathan Crane, and published by the UF/IFAS Horticultural Sciences Department. https://edis.ifas.ufl.edu/hs1426