Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells
oleh: Vasiliki Panagiotakopoulou, Dina Ivanyuk, Silvia De Cicco, Wadood Haq, Aleksandra Arsić, Cong Yu, Daria Messelodi, Marvin Oldrati, David C. Schöndorf, Maria-Jose Perez, Ruggiero Pio Cassatella, Meike Jakobi, Nicole Schneiderhan-Marra, Thomas Gasser, Ivana Nikić-Spiegel, Michela Deleidi
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-10-01 |
Deskripsi
IFN-γ signalling is linked to regional neuronal vulnerability in Parkinson’s disease. The authors show that a PD-associated pathogenic LRRK2 missense mutation increases neuronal susceptibility to immune challenges via negative regulation of AKT phosphorylation and NFAT activation in human iPSC-derived neurons and microglia.