Biological effects of the loss of homochirality in a multicellular organism

oleh: Agnes Banreti, Shayon Bhattacharya, Frank Wien, Koichi Matsuo, Matthieu Réfrégiers, Cornelia Meinert, Uwe Meierhenrich, Bruno Hudry, Damien Thompson, Stéphane Noselli

Format: Article
Diterbitkan: Nature Portfolio 2022-11-01

Deskripsi

Active regulation of chirality, or handedness, is crucial for life. Here, the authors describe assays to characterise proteome chirality in vivo and show that errors degrade enzyme activity triggering tumour formation and reduced lifespan.