<i>DoseMRT</i>: A Software Package for Individualised Monte Carlo Dose Calculations of Synchrotron-Generated Microbeam Radiation Therapy

oleh: Jason Paino, Matthew Cameron, Matthew Large, Micah Barnes, Elette Engels, Sarah Vogel, Moeava Tehei, Stéphanie Corde, Susanna Guatelli, Anatoly Rosenfeld, Michael Lerch

Format: Article
Diterbitkan: MDPI AG 2023-06-01

Deskripsi

This work describes the creation and experimental validation of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>D</mi><mi>o</mi><mi>s</mi><mi>e</mi><mi>M</mi><mi>R</mi><mi>T</mi></mrow></semantics></math></inline-formula>, a new software package, and its associated workflow for dose calculations in synchrotron-generated broad beam and microbeam radiation treatment fields. The <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>D</mi><mi>o</mi><mi>s</mi><mi>e</mi><mi>M</mi><mi>R</mi><mi>T</mi></mrow></semantics></math></inline-formula> software package allows users to import CT DICOM datasets into Geant4 for Monte Carlo dose calculations. It also provides basic treatment planning capabilities, simplifying the complexity of performing Geant4 simulations and making our Monte Carlo dose calculation algorithm accessible to a broader range of users. To demonstrate the new package, dose calculations are validated against experimental measurements performed in homogeneous water tank phantoms and the anatomically complex Alderson Radiotherapy Phantom for both broad-beam and microbeam configurations. Additionally, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>D</mi><mi>o</mi><mi>s</mi><mi>e</mi><mi>M</mi><mi>R</mi><mi>T</mi></mrow></semantics></math></inline-formula> is successfully utilised as the primary method for patient-specific treatment prescription in an in vivo experiment involving tumour-bearing rats at the Imaging and Medical Beamline of the Australian Synchrotron.